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It was a young pathologist, Cuthbert Dukes, working at St Mark’sHospital in London who ?rst published a paper in 1930 noting the hereditary compo-nent of the disease [ 4]. Subjects with dysthymia alone (chroniclow mood) had lower red blood cell levels (RBC-levels) of folate thanpatients who were never depressed, even though their serum levels didnot differ. The decision to retain or exchange the fixation devicemay be difficult

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FXTAS usually has onset at about age 60 years andaffects men and only rarely women. But people from Eastern countries and Native Americanstend to look down to show respect to the person talking.

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There is an urgent need to reverse the worrisomeepidemic trend of obesity, diabetes, and metabolicsyndrome which threatens to halt or even reverse theprogress gained in reducing CVD mortality.
 

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